トップ > ニュース一覧 > 記事
Roche secures Zealand obesity drug candidate for up to $5.3 billionン
Roche secures Zealand obesity drug candidate for up to $5.3 billion
Logo of Swiss drugmaker Roche is seen in Basel · Reuters

ZURICH (Reuters) -Roche acquired rights to an obesity therapy by Danish biotech firm Zealand Pharma in a collaboration deal worth up to $5.3 billion, as the Swiss pharmaceutical company seeks to boost its prospects in the booming weight-loss market.

The deal covering the compound petrelintide, announced by Roche on Wednesday, marks renewed efforts to catch up with weight-loss market leaders Novo Nordisk and Eli Lilly.

"We are excited to collaborate with Zealand Pharma and develop this promising therapy, which we hope will provide people living with obesity and related comorbidities a new treatment option," Teresa Graham, CEO of Roche Pharmaceuticals said of the exclusive collaboration and licensing agreement.

Under the accord, Zealand Pharma will receive upfront cash payments of $1.65 billion with the possibility of milestone payments taking the total sum up to $5.3 billion, depending mainly on phase 3 trials and sales development, Roche said.

Zealand is currently testing petrelintide in overweight or obese individuals without type 2 diabetes in a mid-stage study.

Petrelintide belongs to a class of drugs known as long-acting amylin analogues, which mimic a hormone called amylin that is co-secreted with insulin in response to ingested nutrients.

Zealand and Roche will jointly commercialize petrelintide in the United States and Europe, and the Swiss company will obtain exclusive commercialisation rights in the rest of the world.

Profits and losses for petrelintide, as well as a fixed-dose combination with Roche's CT-388, will be shared on a 50/50 basis in the U.S. and Europe, said Roche.

The transaction is expected to close in the second quarter.

Roche, which in late 2023 agreed to buy drug developer Carmot, said in September three early-stage obesity and diabetes drug candidates from that acquisition have a combined potential of over 3 billion Swiss francs in annual sales.

(Writing by Miranda Murray and Dave Graham, Editing by Rachel More and Ludwig Burger)

続きを読む

Advertisement

Advertisement

あなたにおすすめ
Tom Holland Tried to Buy His Own Non-Alcoholic Beer at Target, and His ID Wasn’t Accepted: ‘I Couldn’t Prove My Age’
Tom Holland Tried to Buy His Own Non-Alcoholic Beer at Target, and His ID Wasn’t Accepted: ‘I Couldn’t Prove My Age’
Axelle/Bauer-Griffin/FilmMagic
University of Windsor students speak out against job cuts amid $30M budget shortfall
University of Windsor students speak out against job cuts amid $30M budget shortfall
More than 150 students, staff and faculty members marched the streets near the University of Windsor Tuesday morning to protest recent job cuts and service changes at the school.
Did a Thrilling FBI Just Stealth-Introduce a Love Interest for Maggie?
Did a Thrilling FBI Just Stealth-Introduce a Love Interest for Maggie?
The following contains spoilers from the Feb. 18 episode of CBS’ FBI.

Advertisement

Advertisement

‘Captain America: Brave New World’s Julius Onah On Why He Thanks Octavia Spencer In Movie Credits
‘Captain America: Brave New World’s Julius Onah On Why He Thanks Octavia Spencer In Movie Credits
Julius Onah is the director behind Marvel’s Captain America: Brave New World, and in the “Special Thanks” credits, there was a shoutout to Octavia Spencer.
‘Yellowjackets’ Star Melanie Lynskey on Shauna’s Growth in Season 3: She’s ‘Relaxing into Herself’
‘Yellowjackets’ Star Melanie Lynskey on Shauna’s Growth in Season 3: She’s ‘Relaxing into Herself’
For Melanie Lynskey, playing cannibalistic crash survivor Shauna Shipman on “Yellowjackets” is about walking the line between comedy and drama.
Wildfires continue to burn in North and South Carolina, prompting evacuations and a state of emergency
Wildfires continue to burn in North and South Carolina, prompting evacuations and a state of emergency
The National Weather Service issued “increased fire danger” alerts for North and South Carolina on Tuesday as firefighter crews continued to battle more than 170 wildfires across both states since last weekend. The fires have prompted evacuations in certain areas and a state of emergency declaration.

Advertisement

アクセスランキング
Kings Rolling the Dice on Goaltending - A Risky Deadline Decision
The Los Angeles Kings have recently undergone a self-inflicted fall from grace. Of course, most of their wounds are self-inflicted, but the fumbling at the worst time of year is a stark reminder of a poorly constructed roster if one considers the team 'championship-caliber.' One of the areas that was previously on stable ground has now shown some pulled roots: goaltending.
Kings Rolling the Dice on Goaltending - A Risky Deadline Decision
A$AP Rocky Found Not Guilty in Shooting Felony Trial
A$AP Rocky was found not guilty on all counts by a Los Angeles jury, ending an exhaustive three-week trial that accused the Harlem-bred rapper (real name Rakim Mayers) of firing a gun at his former friend, A$AP Relli (real name Terell Ephron).
A$AP Rocky Found Not Guilty in Shooting Felony Trial
President of NYU's College Republicans Forced to Resign After Calling Barron Trump an 'Oddity on Campus'
Chip Somodevilla/Getty
President of NYU's College Republicans Forced to Resign After Calling Barron Trump an 'Oddity on Campus'
年収800万を稼げる職業一覧! 難易度や従事するためのポイントを紹介
年収800万を稼げる職業一覧! 難易度や従事するためのポイントを紹介
Who Killed Gabby Petito? Revisiting the Travel Vlogger's Shocking Murder — and the Warning Signs Her Family Claims Went Unnoticed
Gabby Petito/ Instagram
Who Killed Gabby Petito? Revisiting the Travel Vlogger's Shocking Murder — and the Warning Signs Her Family Claims Went Unnoticed
Canadian Natural Resources downgraded, Suncor and Imperial boosted to 'buy'
Canadian Natural Resources (CNQ.TO)(CNQ) shares were downgraded by TPH & Co. on Monday. At the same time, the Houston-based research firm joins a growing camp of analysts favouring Suncor Energy (SU.TO)(SU) and Imperial Oil (IMO.TO)(IMO) amid the risk of U.S. tariffs on Canadian crude.
Canadian Natural Resources downgraded, Suncor and Imperial boosted to 'buy'
Mexico awaits new response from Google on dispute over Gulf of Mexico name before filing lawsuit
MEXICO CITY (AP) — Mexico said Monday it's awaiting a new response from Google to its request that the tech company fully restore the name Gulf of Mexico to its Google Maps service before filing a lawsuit.
Mexico awaits new response from Google on dispute over Gulf of Mexico name before filing lawsuit
Tesla begins mass production of revamped Model Y in Shanghai factory
BEIJING (Reuters) - U.S. automaker Tesla said on Tuesday it has started mass production of the revamped version of its Model Y in its Shanghai factory.
Tesla begins mass production of revamped Model Y in Shanghai factory
Gas prices drop as consumer carbon price ends, but full impact yet to be felt
Gas prices drop as consumer carbon price ends, but full impact yet to be felt
Gas price expert: Trump has 'costly' option to shut Canadian oil out of U.S. refineries
Gas prices fell on average across most Canadian cities over the past week, dropping 1.8 cents per litre of regular fuel, according to data from Kalibrate.
Gas price expert: Trump has 'costly' option to shut Canadian oil out of U.S. refineries
Underrated Senators Defenceman Nikolas Matinpalo Doesn't Deserve To Have His Role Diminished In Ottawa
The inclusion of Nikolas Matinpalo for Finland's Four Nations Faceoff entry raised some eyebrows around this city.
Underrated Senators Defenceman Nikolas Matinpalo Doesn't Deserve To Have His Role Diminished In Ottawa
Toronto police responding to 911 calls 7 minutes faster than a year ago, police chief says
Toronto police are responding faster to 911 calls now than they were a year ago in part because the service has hired more officers, according to the police chief.
Toronto police responding to 911 calls 7 minutes faster than a year ago, police chief says
‘Bookie’ Canceled By Max After Two Seasons
Bookie, the comedy series Chuck Lorre and Nick Bakay created, has been canceled at Max after two seasons.
‘Bookie’ Canceled By Max After Two Seasons
‘Richard II’ Review: Jonathan Bailey Shows Off His Shakespearean Chops in a Stern, Stripped-Down Production
“Nothing in his life became him like the leaving it.” OK, that’s the wrong play since it’s a line from “Macbeth,” but it best sums up Jonathan Bailey’s performance in the new London production of “Richard II”: The actor cranks up several gears the moment his character is forced by usurper Henry Bullingbrook to give up the throne of England for a life of imprisonment in the second half of director Nicholas Hytner’s staging of Shakespeare’s history play. But the fact that Bailey takes time to catch fire is not entirely his fault, since neither Shakespeare nor Hytner make life easy for him. Given that the play is set at the close of the 14th century, it’s no surprise that Hytner believes the play, which depicts the ushering in of a nation’s decades-long succession crisis, needs contemporary reference points. That explains composer Grant Olding’s doom-laden, grinding, low strings that herald a driving rhythm and a light-touch, bitter piano melody opening the production, a clear hat-tip to Nicholas Britell’s Beethoven-tinged theme to “Succession.” It also governs Bob Crowley’s crisp men-in-black-suits design. The antithesis of the exuberantly colored “Guys and Dolls,” the last show to play at Hytner’s physically versatile Bridge Theatre (and which ran almost two years), this limited run of “Richard II” is stripped-down and stern. Gone is the expected heraldry and splendor of the English court in which King Richard traditionally basks. Instead, the audience is arranged in the round observing a traverse-style black runway staging with changing, minimal locations being lifted up through the floor on hydraulics. It makes for welcome fluidity, highly useful in a play that, for the first half at least, moves through an uncomfortable number of locations and a load of exposition.This is a story about the threat to the kingdom and, specifically, Richard, who ruled neither wisely nor well with absolute power by ancient Divine Right. The nation is torn apart by the plots and counterplots of men and their forces loyal to the crown and those backing Henry Bullingbrook, the Duke of Hereford who, successfully as it turns out, puts his eyes on the ultimate prize and steals it.That the tussle for dominance between the men is so potentially dramatic is illustrated by the fact that around fifty years ago, Richard Pasco and Ian Richardson, two leading Shakespeareans of their day, alternated the roles when they led the play in a celebrated RSC production. Here, alas, the balance is uneven. Royce Pierreson is nicely forthright and determined but his performance is unvarying. The wonderfully character-driven abdication scene between the two men is the production’s highpoint, but elsewhere Pierreson’s determination is too one-note. Anyone questioning the wisdom of the star-casting of “Bridgerton” and “Wicked” talent Bailey should bear in mind that he played Cassio in Hytner’s riveting “Othello” at the National Theatre back in 2013 and followed that with an arresting Edgar/Mad Tom opposite Ian McKellen’s King Lear for director Jonathan Munby. As a result, his handling of the language and, crucially, the intent behind it, is entirely easeful. His king is self-satisfied and perfectly petulant, dispatching orders, and often men’s lives, with gleaming disdain. He’s even better when he’s calmly and quietly coming to understand himself and the nature of his previous selfishness in the play’s highly reflective and tender final scenes.But between those extremes of temperament, the living center of the character remains unseen, robbing the production of strength. That’s partly because he has to energize scenes that here lack force. Hytner is unquestionably one of the great directors of Shakespeare, but this production is uncharacteristically undercast in places. Some of the acting proves more proficient than powerful.
‘Richard II’ Review: Jonathan Bailey Shows Off His Shakespearean Chops in a Stern, Stripped-Down Production
Ottawa Senators Defeat Philadelphia Flyers 5-2 in Gritty Road Win
The Ottawa Senators got a grand total of two shots in the third period on Tuesday night and scored on both of them to defeat the Philadelphia Flyers 5-2 at Wells Fargo Center.
Ottawa Senators Defeat Philadelphia Flyers 5-2 in Gritty Road Win
Gold could hit US$3,000 per ounce with 'conflict in every continent'
Gold prices will keep hitting new record highs as the classic flight-to-safety asset shines bright for investors rattled by an increasingly uncertain global status quo.
Gold could hit US$3,000 per ounce with 'conflict in every continent'
Worries spurred by Chinese AI chatbot DeepSeek sink Cameco, TransAlta shares by double-digits
Cameco (CCO.TO)(CCJ) shares dropped as much as 14 per cent on Monday amid a wider sell-off linked to the Chinese artificial intelligence (AI) chatbot DeepSeek.
Worries spurred by Chinese AI chatbot DeepSeek sink Cameco, TransAlta shares by double-digits
Nicole Kidman's Lookalike Teen Daughter Walked the Runway at Paris Fashion Week
Getty images
Nicole Kidman's Lookalike Teen Daughter Walked the Runway at Paris Fashion Week
Explainer-ECB to tackle fundamental questions in strategy assessment
FRANKFURT (Reuters) - The European Central Bank is launching a fresh strategy assessment seen covering some big questions on the way it works - from whether massive bond buys remain a good policy tool, to what role it should play in the fight against climate change.
Explainer-ECB to tackle fundamental questions in strategy assessment
'Doomsday Fish' Washes Ashore Mexico Beach: 'Nobody's Gonna Believe This'
Robert Hayes/storyful
'Doomsday Fish' Washes Ashore Mexico Beach: 'Nobody's Gonna Believe This'

Advertisement